Senior Director, AIRx Medicinal Chemistry

Job overview

The Senior Director, AIRx Medicinal Chemistry is a hybrid role based in Boston, MA. Compensation is $212,000–$333,190 per year, and this position supports the Discovery Automation & Robotics (DAR) group at Takeda Pharmaceutical. This role exists to lead AI-enabled molecular design, applying deep SAR judgment and directing CRO synthesis to accelerate drug discovery. The director will challenge computational outputs and integrate expert chemistry thinking to deliver differentiated medicines to the clinic.

What you'll do

• Design and optimize drug candidates using deep SAR intuition, multi-parameter optimization, and ADME-embedded design principles.
• Integrate AI/ML-generated design proposals with medicinal chemistry judgment.
• Partner closely with Computational Chemistry colleagues to close DMTA cycles rapidly.
• Provide strategic oversight of CRO synthesis programs.
• Embed selectivity, developability, and IP considerations into design decisions.

What we're looking for

Skills & competencies

full-time

hybrid

boston ma

medicinal chemistry

ai-driven drug design

drug discovery

leadership

sar

cro management

$212k-$333k

Work arrangement

• Weekend coverage required

Benefits & perks

• Medical, dental, vision, 401(k) with match, tuition reimbursement, paid vacation, sick time.

Why this role

Work at the frontier of AI-enabled drug design, autonomous environment, high-impact leadership role.

About the employer

Takeda Pharmaceutical is hiring for this role. Industry: Pharmaceutical Preparation Manufacturing. Sector: 32.