Principal Software Engineer

Job overview

The Principal Software Engineer role is an onsite, full-time position in Houston, TX. Compensation is not specified. The engineer works across Baylor Genetics’ software ecosystem, supporting genetic testing workflows, clinical reporting, and data-driven insights that affect patient care. The role sets technical direction and leads the design and development of scalable, secure software systems. Collaboration with geneticists, bioinformaticians, laboratory professionals, and product leaders helps improve workflows and deliver reliable software for clinical use.

What you'll do

• Lead architecture, design, and development of complex software systems
• define engineering standards and technical roadmaps
• translate business needs into scalable, secure, maintainable solutions
• conduct technical reviews and guide system design
• mentor engineers
• lead root-cause analysis and resolve complex issues
• evaluate emerging technologies
• partner with product, laboratory, and bioinformatics teams to improve workflows
• ensure security, privacy, and regulatory compliance
• contribute to digital innovation.

What we're looking for

Skills & competencies

principal software engineer

baylor genetics

houston tx

full-time

onsite

c#

.net

react

typescript

genetic testing

clinical reporting

software architecture

Work arrangement

• Weekend coverage required

Why this role

Requires expert C# and .NET proficiency, extensive React and TypeScript experience, and at least 10 years of professional software engineering experience. Healthcare, clinical diagnostics, genomics, laboratory workflows, and regulated-environment experience are preferred.

About the employer

Baylor Miraca Genetics Laboratories, LLC is hiring for this role. Industry: Medical Laboratories. Sector: 62.