Clinical Data Scientist

Job overview

The Clinical Data Scientist role is hybrid, with three onsite days in the Indianapolis, IN metro area; regional or Eastern Time candidates may be considered with onsite travel. Compensation is not specified. The role supports clinical development teams by developing digital twins and quantitative analyses for clinical trial design and evidence-based development decisions. The position exists to translate clinical-development questions into interpretable simulations and analyses that inform protocol design, patient selection, endpoints, dosing, operational planning, and decisions under uncertainty. The scientist collaborates with clinical scientists, physicians, biostatisticians, pharmacometricians, data scientists, engineers, and other stakeholders to build, validate, and responsibly apply digital-twin methods.

What you'll do

• Lead design, development, and evaluation of digital twins using clinical trial and relevant external data
• combine mechanistic, statistical, causal, and machine-learning approaches
• define use cases with clinical and quantitative experts
• assess calibration, validation, robustness, transportability, uncertainty, and practical relevance
• develop reproducible workflows and reusable components
• evaluate trial-design options and scenarios
• integrate clinical, biomarker, imaging, digital health, omics, patient-reported, and real-world data where relevant
• communicate assumptions and limitations
• ensure models are interpretable, auditable, reproducible, and appropriately governed.

What we're looking for

Skills & competencies

clinical data scientist

indianapolis in metro

hybrid

three onsite days

digital twins

clinical trial simulation

ai and machine learning

clinical development

quantitative decision support

python

phd required

contractor full-time

Work arrangement

• Weekend coverage required

Why this role

PhD in a quantitative field required; demonstrated digital-twin, virtual-patient, disease-progression, or clinical-trial simulation experience required; strong programming in Python, R, or comparable language; hybrid with three onsite days; contractor full-time enterprise project engagement.

About the employer

Xenon7 is hiring for this role. Industry: Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology). Sector: 54.