Principal Scientist, Biomarker Development

Job overview

The Principal Scientist, Biomarker Development position is onsite in Cambridge, MA, with an annual salary of $175,000–$225,000. Scholar Rock develops treatments for spinal muscular atrophy and other rare neuromuscular diseases, with a focus on muscle-targeted approaches. The scientist leads biomarker strategy and execution across preclinical neuromuscular programs, connecting discovery research to early clinical development. The role supports program decisions by developing fit-for-purpose assays, interpreting biomarker data, and translating biological hypotheses into clinically informative approaches.

What you'll do

• Develop biomarker strategies for neuromuscular preclinical programs
• advise cross-functional teams on biomarker selection and interpretation
• identify risks and gaps in biomarker plans
• manage CROs and design rodent pharmacology studies
• lead biomarker assay design, development, qualification, and implementation
• conduct and troubleshoot experiments as needed
• analyze datasets and communicate implications for program decisions.

What we're looking for

Skills & competencies

principal scientist

biomarker development

cambridge ma

scholar rock

onsite

full-time

$175k–$225k

neuromuscular disease

preclinical research

biomarker assays

translational science

phd required

Work arrangement

• Weekend coverage required

Why this role

Requires a PhD in a relevant discipline and eight or more years of biotech or pharmaceutical R&D experience, preferably in neuromuscular disease. The role includes an active laboratory presence as needed.

About the employer

Scholar Rock is hiring for this role. Industry: Research and Development in Biotechnology (except Nanobiotechnology). Sector: 54.