Principal Investigator (MD/DO), Clinical Trials

Job overview

The Principal Investigator (MD/DO), Clinical Trials role is onsite in Columbus, OH. Compensation is not specified. The position leads clinical trials and collaborates with study teams and sponsors to support research quality and participant safety. The role provides physician leadership and medical oversight throughout assigned trials. It supports safe participant screening and study conduct, reviews safety and clinical data, and guides site staff while coordinating with sponsors, contract research organizations, institutional review boards, and company leadership.

What you'll do

• Provide medical oversight and clinical leadership for assigned trials
• review participant eligibility and screening outcomes
• review adverse events, serious adverse events, and safety trends. Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments. Guide Sub-Investigators, Clinical Research Coordinators, registered nurses, and site staff
• collaborate with sponsors, CROs, IRBs, and leadership
• participate in study visits and meetings
• review laboratory results, ECGs, vital signs, and other assessments.

What we're looking for

Skills & competencies

principal investigator

physician

md

do

clinical trials

medical oversight

patient safety

clinical research

columbus oh

system one

onsite

Work arrangement

• Weekend coverage required

Benefits & perks

• Eligible employees may access medical, dental, vision, spending accounts, life insurance, voluntary plans, and a 401(k) plan.

Why this role

Requires an MD or DO, active unrestricted Ohio medical license, board certification, and prior clinical research experience as a principal investigator, sub-investigator, or clinical research physician. DEA registration may be required by study protocols.

About the employer

System One is hiring for this role. Industry: All Other Outpatient Care Centers. Sector: 62.