Director, Pharmacometrics & Clinical Pharmacology

Job overview

Compensation is $200,000–$230,000 per year. The Director, Pharmacometrics & Clinical Pharmacology role is listed in Madison, WI; the work arrangement is not specified. for the Madison listing; the description gives a Wisconsin pay range of $200,000–$230,000 and a California range of $230,000–$255,000. The role supports Arrowhead Pharmaceuticals’ development of RNA interference therapeutics. The director leads pharmacometrics and clinical pharmacology strategy across development programs, guiding modeling, dose optimization, clinical trial design, regulatory documentation, and cross-functional decisions. This work supports scientifically grounded development and regulatory submissions for the company’s therapeutics.

What you'll do

• Lead pharmacometrics and clinical pharmacology across development programs
• develop model-informed drug development strategies, including population PK/PD, exposure-response, translational modeling, and dose optimization
• support clinical pharmacology strategies for studies and special populations
• oversee internal and external PK/PD analyses
• contribute to regulatory submissions and health authority interactions
• author and review clinical pharmacology documents
• collaborate with cross-functional teams
• present analyses and recommendations to project teams and senior leadership.

What we're looking for

Skills & competencies

pharmacometrics

clinical pharmacology

director

rnai therapeutics

population pk/pd

exposure-response

dose optimization

regulatory submissions

madison wi

arrowhead pharmaceuticals

phd required

12+ years experience

Work arrangement

• Weekend coverage required

Benefits & perks

• Competitive salaries and an excellent benefit package.

Why this role

The posting requires a PhD or equivalent advanced degree and 12+ years of relevant experience, including late-stage development and global regulatory submissions; deep population PK/PD modeling expertise is required.

About the employer

Arrowhead Pharmaceuticals is hiring for this role. Industry: Biological Product (except Diagnostic) Manufacturing. Sector: 32.