Principal Investigator (MD/DO)

Job overview

The Principal Investigator (MD/DO) role is onsite in Indianapolis, IN, and compensation is not specified. System One describes itself as a provider of outsourced services and workforce solutions; this position supports a clinical research site and its trials. The physician provides medical oversight and clinical leadership for assigned trials, with a focus on participant safety, data quality, and protocol compliance. The role guides study staff, reviews clinical information and safety events, and collaborates with sponsors, contract research organizations, institutional review boards, and company leadership throughout trial activities.

What you'll do

• Provide medical oversight and clinical leadership for assigned clinical trials
• review participant eligibility and screening outcomes
• review adverse events, serious adverse events, and safety trends
• perform or oversee study-specific medical assessments
• guide sub-investigators, coordinators, registered nurses, and site staff
• collaborate with sponsors, CROs, IRBs, and leadership
• participate in study visits and meetings
• review laboratory results, ECGs, vital signs, and other assessments
• support safety reporting, documentation, and data-query resolution
• maintain compliance with protocols, SOPs, ICH-GCP, FDA regulations, and state requirements.

What we're looking for

Skills & competencies

principal investigator

md

do

full-time

onsite

indianapolis in

clinical research

clinical trials

medical oversight

participant safety

ich-gcp

fda regulations

indiana medical license

Work arrangement

• Weekend coverage required

Benefits & perks

• Eligible employees may access medical, dental, vision, spending accounts, life insurance, voluntary plans, and a 401(k) plan.

Why this role

MD or DO and active, unrestricted Indiana medical license required; prior clinical research physician experience and board certification required; DEA registration if required by study protocols.

About the employer

System One is hiring for this role. Industry: All Other Outpatient Care Centers. Sector: 62.