Senior Scientist II, Discovery Analytical Chemistry

Job overview

The Senior Scientist II, Discovery Analytical Chemistry role is onsite in Madison, WI, with a stated Wisconsin pay range of $130,000–$150,000 per year. The role supports Arrowhead Pharmaceuticals’ drug development programs and its work developing RNA interference-based medicines. The scientist leads analytical method development, characterization, and testing activities for pharmaceutical development programs. The role provides technical oversight of external partners, collaborates across development, manufacturing, quality, and regulatory teams, and contributes analytical data and documentation to product development and regulatory submissions.

What you'll do

• Design, develop, optimize, qualify, and transfer analytical methods
• lead characterization studies for drug substances, intermediates, and related materials
• assess identity, purity, potency, impurities, and stability
• interpret data and recommend actions
• support method lifecycle management and troubleshooting
• oversee analytical work at CDMOs
• review external protocols, reports, deviations, investigations, and technical documents
• monitor project timelines and deliverables
• collaborate with cross-functional teams
• contribute to control strategies and specifications
• author and review analytical sections of regulatory submissions
• support regulatory questions and inspections
• ensure compliance with applicable GMP, ICH, FDA, and EMA requirements
• participate in quality investigations, change controls, risk assessments, and CAPA as needed.

What we're looking for

Skills & competencies

senior scientist ii

discovery analytical chemistry

analytical method development

drug characterization

aoc

hplc

uhplc

gmp

regulatory submissions

madison wi

arrowhead pharmaceuticals

$130k–$150k/year

Work arrangement

• Weekend coverage required

Benefits & perks

• Competitive salary and an excellent benefit package.

Why this role

The role focuses on antibody oligonucleotide conjugate (AOC) characterization and requires a relevant degree plus pharmaceutical industry experience. SEC-MALS experience is preferred but not required.

About the employer

Arrowhead Pharmaceuticals is hiring for this role. Industry: Biological Product (except Diagnostic) Manufacturing. Sector: 32.