Machine Learning Engineer, Discovery Applications

Job overview

The Machine Learning Engineer, Discovery Applications role is onsite in San Francisco, CA. The stated annual compensation range is $180,000–$220,000. Mithrl is building an AI Co-Scientist to turn biological data into insights and support scientific discovery. The engineer builds end-to-end scientific applications and workflows that help scientists make decisions across drug discovery and preclinical development. The role combines machine-learning models, statistical methods, biological domain logic, and agentic reasoning, while validating that results are accurate, reproducible, and interpretable.

What you'll do

• Build applications for biomarker identification, target discovery and validation, small-molecule workflows, and gene therapy programs
• develop analyses and multi-step reasoning flows
• integrate ML models, statistical methods, pathway context, simulation tools, and biological logic
• extend applications to new data modalities
• build reusable Design of Experiments frameworks
• improve AI orchestration
• collaborate with ML engineering, bioinformatics, and data-ingestion teams
• validate scientific correctness and reproducibility.

What we're looking for

Skills & competencies

machine learning engineer

discovery applications

san francisco ca

mithrl

computational biology

drug discovery

preclinical development

python

ai co-scientist

$180,000–$220,000 annually

Work arrangement

• Weekend coverage required

Benefits & perks

• PPO medical, dental, and vision coverage through Anthem
• 401(k) plans.

Why this role

The listing describes the role as ML Engineer, Discovery Applications; the source title is Member of Technical Staff, Discovery Applications.

About the employer

Mithrl is hiring for this role. Industry: Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology). Sector: 54.