Peptide Synthesis Chemist/Scientist

Job overview

The Peptide Synthesis Chemist/Scientist role is onsite in Morrisville, NC. The posting states competitive compensation but does not specify a numeric amount. Synoligo Biotechnologies is a contract research and development organization specializing in complex and modified oligonucleotides and supporting research, diagnostic, and therapeutic programs. The role leads peptide synthesis projects from design and feasibility through purification, characterization, documentation, and delivery. It contributes to customer research and development programs by producing and analyzing peptides, resolving technical challenges, and coordinating work across laboratory and operational teams.

What you'll do

• Design and execute peptide synthesis strategies, primarily using solid-phase peptide synthesis
• assess sequence feasibility and technical risks
• perform resin selection, coupling, deprotection, cleavage, and related operations
• optimize yield, purity, reproducibility, and scalability
• purify peptides using preparative and semi-preparative chromatography including reverse-phase HPLC
• characterize products using analytical HPLC and LC-MS or mass spectrometry
• troubleshoot synthesis and analytical challenges
• maintain experimental records and prepare technical summaries and customer data packages
• manage multiple projects
• collaborate with analytical, quality, operations, and commercial colleagues
• support technology transfer, scale-up, laboratory safety, equipment readiness, and inventory
• provide technical guidance to junior scientists.

What we're looking for

Skills & competencies

peptide synthesis chemist/scientist

morrisville nc

synoligo biotechnologies

solid-phase peptide synthesis

spps

reverse-phase hplc

lc-ms

peptide purification

analytical chemistry

laboratory research

customer projects

onsite laboratory

Work arrangement

• Weekend coverage required

Benefits & perks

• Medical, dental, and vision insurance
• 401(k) with company match
• paid time off
• flexible work schedule
• opportunity to help shape a growing commercial function.

Why this role

Requires at least five years of direct hands-on peptide synthesis experience and a bachelor’s degree in a related discipline. Limited travel may be requested; occasional schedule flexibility may be needed for time-sensitive laboratory operations.

About the employer

Synoligo Biotechnologies Inc. is hiring for this role. Industry: Testing Laboratories and Services. Sector: 54.